Palladium/rhodium-catalyzed four-component carbonylative difunctionalization of alkynes: Regio- and stereoselective esterification/selenylation to access β-selenyl acrylates

IF 6.5 1区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Catalysis Pub Date : 2025-04-30 DOI:10.1016/j.jcat.2025.116170

Fengxiang Zhu , Huanan Wu , Xiao-Feng Wu

引用次数: 0

Abstract

The development of efficient catalytic systems for 1,2-difunctionalization of alkynes remains a challenge due to limitations in substrate scope, selectivity, and step economy. Herein, we report a novel palladium/rhodium catalytic system for the four-component difunctionalization of alkynes, which enables concurrent incorporation of ester and selenyl groups with excellent regio- and stereoselectivity. This protocol utilizes readily available alkynes, phenols, carbon monoxide, and selenium reagents to construct β-selenyl acrylates in a single operation, demonstrating broad functional group tolerance and scalability.

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钯/铑催化炔的四组分羰基化双官能化：区域和立体选择性酯化/硒化反应得到β-硒基丙烯酸酯

由于底物范围、选择性和步骤经济性的限制，开发高效的1,2-炔烃双官能化催化体系仍然是一个挑战。在此，我们报道了一个新的钯/铑催化体系，用于炔的四组分双官能化，它可以同时结合具有优异的区域选择性和立体选择性的酯和硒基。该方案利用现成的炔、酚、一氧化碳和硒试剂在一次操作中构建β-硒基丙烯酸酯，展示了广泛的功能基团耐受性和可扩展性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Catalysis 工程技术-工程：化工

CiteScore

12.30

自引率

5.50%

发文量

447

审稿时长

31 days

期刊介绍： The Journal of Catalysis publishes scholarly articles on both heterogeneous and homogeneous catalysis, covering a wide range of chemical transformations. These include various types of catalysis, such as those mediated by photons, plasmons, and electrons. The focus of the studies is to understand the relationship between catalytic function and the underlying chemical properties of surfaces and metal complexes. The articles in the journal offer innovative concepts and explore the synthesis and kinetics of inorganic solids and homogeneous complexes. Furthermore, they discuss spectroscopic techniques for characterizing catalysts, investigate the interaction of probes and reacting species with catalysts, and employ theoretical methods. The research presented in the journal should have direct relevance to the field of catalytic processes, addressing either fundamental aspects or applications of catalysis.