Access to N‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides and Related Derivatives

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-05-01 DOI:10.1002/anie.202505478

Filip G. Zivkovic, Fritz Bahns, Che-Ming Hsu, Franziska Schoenebeck

引用次数: 0

Abstract

This work presents the first general synthetic access to N‐CH₂F and N‐CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds. The synthetic approach employs N‐CH2F and N‐CHRF carbamoyl fluorides as versatile strategic building blocks, which can be efficiently synthesized in a single step directly from readily available amines or imines.

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N‐单氟甲基化（硫代）氨基甲酸酯、甲酰胺、烷基酰胺及相关衍生物的获取

这项工作首次提出了N - ch2f和N - CHRF氨基甲酸酯、硫氨基甲酸酯、甲酰胺、烷基酰胺和相关化合物的一般合成途径。该合成方法采用N‐CH2F和N‐CHRF氨甲酰氟化物作为通用的战略构建块，可以直接从现成的胺或亚胺中一步有效地合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.