Ce(OTf)3-Catalyzed Asymmetric 6π Cyclization of Triaryldivinyl Ketones

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-01 DOI:10.1021/acs.orglett.5c01081

Liu Li, Hao Wei, Zhanhui Yang, Jiaxi Xu

引用次数: 0

Abstract

The rare-earth Ce(OTf)₃-catalyzed asymmetric 6π cyclization of triaryldivinyl ketones is realized, affording methyl (R,E)-1-aryl-2-arylmethylidene-3-hydroxy-1,4-dihydronaphthalene-2-carboxylates in moderate to good yields with good to excellent enantioselectivities. The reaction provides a new strategy for the construction of optically active 3-hydroxy-1,4-dihydronaphthalene-2-carboxylic acid derivatives.

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Ce(OTf)3催化三芳基二乙烯基酮的不对称6π环化

稀土铈（OTf）3催化三芳基二乙烯基酮实现了不对称6π环化反应，得到了中~高产率的甲基（R，E）-1-芳基-2-芳基甲基-3-羟基-1,4-二氢萘-2-羧酸酯，并具有良好的对映选择性。该反应为构造具有光学活性的3-羟基-1,4-二氢萘-2-羧酸衍生物提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.