IRF6 hits the sweet spot

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-05-01 DOI:10.1016/j.stem.2025.04.002

Jane Reznick, Carien M. Niessen

引用次数: 0

Abstract

Glucose serves as an essential energy source for cells. In this issue, Lopez-Pajares et al.¹ uncover a role for glucose uncoupled from its energetic function. During epidermal differentiation, free glucose accumulates and binds the pro-differentiation transcription factor IRF6, promoting its dimerization and DNA binding to activate genes that drive differentiation.

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IRF6达到了最佳点

葡萄糖是细胞必需的能量来源。在这一期中，Lopez-Pajares等人揭示了葡萄糖从其能量功能中解耦的作用。在表皮分化过程中，游离葡萄糖积累并结合促分化转录因子IRF6，促进其二聚化和DNA结合，激活驱动分化的基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.