The [N-methyl-3H] group and tritium decay catastrophe

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2025-02-18 DOI:10.1007/s10967-025-10016-2

Crist N. Filer

引用次数: 0

Abstract

Tritium labelled radioligands have been extremely useful to advance neurochemistry discovery. In particular, [N-methyl-³H] radioligands have been exceptionally valuable in receptor binding and other neurochemical assays because of their very high specific activity. Regarding [N-methyl-³H] labelled substances, examination of one of them has revealed its long-term retention of specific activity which is consistent with the phenomenon of tritium decay catastrophe.

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[n -甲基- 3h]基团和氚衰变突变

氚标记的放射性配体在推进神经化学发现方面非常有用。特别是，[n -甲基- 3h]放射配体由于其非常高的特异性活性，在受体结合和其他神经化学分析中特别有价值。对于[n -甲基- 3h]标记的物质，其中一种物质的检测显示其长期保持比活性，这与氚衰变突变现象一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.