Exploration of the optimal retention method in vivo for stem cell therapy: Low-intensity ultrasound preconditioning

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2025-04-30 DOI:10.1016/j.reth.2025.04.012

Haopeng Xu , Yilin Tang , Wenjing Mao, Liu Wu, Yiqing Zhou, Juan Deng, Wentao Tang, Xinfang Xiao, Yi Xia, Yan Wang

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引用次数: 0

Abstract

Bone marrow mesenchymal stem cells (BMSCs) are pluripotent and self-renewing, exerting a crucial role in the domain of regenerative medicine. Nevertheless, BMSCs encounter challenges such as low cell viability and inadequate homing during transplantation, thereby restricting their therapeutic efficacy. Hence, current research is concentrated on identifying optimal retention approaches following BMSCs transplantation to enhance its effectiveness. Low-intensity ultrasound (LIUS) has been verified as an efficacious method to enhance the performance of BMSCs. We established a skin trauma model and assessed the therapeutic effect of LIUS-preconditioned BMSCs. The results demonstrated that pretreatment with LIUS could expedite wound healing and effectively diminish scar formation post-transplantation by promoting proliferation capacity, reinforcing anti-apoptotic attributes, improving homing ability, and significantly enhancing the transplantation effect of BMSCs. These discoveries imply that LIUS might constitute a promising strategy for attaining optimal retention after stem cell transplantation in regenerative medicine and wound repair therapy.

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探索干细胞治疗的最佳体内保留方法：低强度超声预处理

骨髓间充质干细胞（BMSCs）具有多能性和自我更新能力，在再生医学领域发挥着重要作用。然而，骨髓间充质干细胞在移植过程中遇到细胞活力低和归巢不足等挑战，从而限制了其治疗效果。因此，目前的研究集中在确定骨髓间充质干细胞移植后的最佳保留方法以提高其有效性。低强度超声（LIUS）已被证实是提高骨髓间充质干细胞性能的有效方法。我们建立了皮肤创伤模型，并评估了lius预处理骨髓间充质干细胞的治疗效果。结果表明，LIUS预处理可促进骨髓间充质干细胞的增殖能力，增强抗凋亡属性，提高归巢能力，显著提高骨髓间充质干细胞的移植效果，从而促进移植后创面愈合，有效减少移植后瘢痕形成。这些发现表明，LIUS可能是再生医学和伤口修复治疗中干细胞移植后获得最佳保留的一种有希望的策略。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.