How to enhance the recognition activity of molecularly imprinted polymer sites: a review

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-04-25 DOI:10.1016/j.trac.2025.118278

Pan Wang , Lihong Zhang , Lu Liu , Danqing Shen , Kai Yu , Yuhong Jiang , Yongquan Zhou , Yanan Huang , Jianming Pan

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引用次数: 0

Abstract

Molecularly imprinted polymers (MIPs) have emerged as significant tools in various domains, including fine chemistry and biomedicine, owing to their capacity for selective recognition of target molecules. While substantial progress has been made in MIP preparation techniques and application development, a systematic understanding of strategies to enhance their recognition activity remains underexplored. This review provides a comprehensive overview of the strategies for precisely regulating the imprinting process and improving the recognition separation efficacy. The role of theoretical modeling and experimental titration in designing functional monomers with precise molecular matching has been emphasized. Enhancing site-specific interactions by increasing the quality and density of recognition sites. The review further investigates adsorption and desorption mechanisms in efficient recognition processes, highlighting their significance in practical applications. This review aims to serve as a critical resource for advancing MIP synthesis, optimizing active site functionality, and achieving superior separation performance in complex sample matrices.

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如何提高分子印迹聚合物位点的识别活性

分子印迹聚合物（MIPs）由于其选择性识别目标分子的能力，已成为包括精细化学和生物医学在内的各个领域的重要工具。虽然在MIP制备技术和应用开发方面取得了实质性进展，但对加强其识别活动的策略的系统理解仍未得到充分探索。本文就精确调控印迹过程和提高识别分离效率的策略作一综述。强调了理论建模和实验滴定在设计具有精确分子匹配的功能单体中的作用。通过提高识别站点的质量和密度来增强站点特定的相互作用。综述进一步探讨了高效识别过程中的吸附和解吸机理，强调了它们在实际应用中的意义。本综述旨在为推进MIP合成，优化活性位点功能，以及在复杂样品矩阵中实现卓越的分离性能提供关键资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.