You are what you eat: metabolic recycling of phagocytosed bacteria modulates macrophage immunity

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-04-28 DOI:10.1038/s41392-025-02222-x

Syamantak Basu, Manuela Rossol

引用次数: 0

Abstract

In a recent study published in Nature, Lesbats et al.¹ show that phagocytosed bacteria can be recycled by macrophages to serve as an alternative nutrient source. Bacterial cAMP was identified as a signal for macrophages to differentiate between dead and live bacteria and to adjust the inflammatory response accordingly.

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人如其食：被吞噬细菌的代谢循环调节巨噬细胞免疫

在最近发表在《自然》杂志上的一项研究中，Lesbats等人1表明，被吞噬的细菌可以被巨噬细胞回收，作为一种替代的营养来源。细菌cAMP被认为是巨噬细胞区分死细菌和活细菌并相应地调整炎症反应的信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.