An overview of the synthesis of biheterocyclic compounds featuring four-membered rings containing nitrogen, oxygen, or sulfur

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-23 DOI:10.1016/j.tet.2025.134679

Soumyadip Das , Badruzzaman Choudhury , Sameer Chauhan , M.M. Balamurali , Kaushik Chanda

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Abstract

Biheterocyclic compounds with Four-membered rings are crucial in medicinal chemistry due to their ability to incorporate diverse functional groups, enhancing drug efficacy and selectivity. Their unique frameworks provide opportunities for developing innovative therapeutic agents. In this review, we have discussed the various synthetic protocols for the syntheses of four membered heterocycles consist with linked, spiro, fused heterocyclic compounds. This study provides a comprehensive analysis of the latest synthetic methodologies developed to overcome existing limitations and challenges in the preparation of biheterocyclic derivatives featuring four-membered rings. It emphasizes the importance of addressing issues such as ring strain, selectivity, and scalability while highlighting innovative approaches that pave the way for more efficient and sustainable synthesis. The focus is directed toward the biological significance of these derivatives, showcasing their potential as valuable frameworks in the discovery and development of novel therapeutic agents.

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概述以含氮、氧或硫的四元环为特征的双杂环化合物的合成

具有四元环的双杂环化合物能够结合多种官能团，提高药物的疗效和选择性，在药物化学中至关重要。它们独特的框架为开发创新治疗剂提供了机会。本文综述了四元杂环化合物的各种合成方法，包括连接杂环化合物、螺旋杂环化合物和熔合杂环化合物。本研究全面分析了最新的合成方法，以克服现有的限制和挑战，在制备具有四元环的双杂环衍生物。它强调了解决环应变、选择性和可扩展性等问题的重要性，同时强调了为更有效和可持续的合成铺平道路的创新方法。重点是针对这些衍生物的生物学意义，展示它们在发现和开发新的治疗药物中作为有价值框架的潜力。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.