Silver-catalyzed direct decarboxylative CH functionalization of azauracils with aliphatic carboxylic acids

Abstract

We propose a novel method for the CH alkylation of azauracils using aliphatic carboxylic acids as alkyl radical precursors, catalyzed by silver. This technique marks a substantial progress in organic synthesis, providing a flexible and effective route for azauracils modification. The method has been successfully applied to a diverse array of primary, secondary and tertiary carboxylic acids, highlighting its broad utility and reliability. The applicability of this method allows the preparation of a range of alkylated azauracil derivatives, which are potential intermediates for the creation of new pharmaceuticals, agrochemicals, and materials.