Profiling the Ocular Landscape of sEVs miRNAs: Mechanisms and Applications

IF 3 2区医学 Q1 OPHTHALMOLOGY

Experimental eye research Pub Date : 2025-04-23 DOI:10.1016/j.exer.2025.110396

Yifei Wu, Jiaqi Zhao, Xiaohe Lu

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Abstract

In this review, we comprehensively discuss the application of sEVs miRNAs in ophthalmic diseases by examining their basic characteristics and clinical application potential. Initially, we provide an overview of sEVs, including their definition, source, and functions, while particularly highlighting the importance of miRNAs contained in sEVs and its prospects in the treatment of ocular diseases. Subsequently, the structure and composition of sEVs as well as the biological functions of their encapsulated miRNAs, which expands the current knowledge about their roles in ophthalmic physiology and pathology. In addition, the functions of sEVs miRNAs in the growth of ocular tissues, ocular tissue homeostasis, and common eye diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy, are discussed. The application potential of sEVs miRNAs as diagnostic biomarkers and drug delivery systems for ophthalmic conditions and therapeutic value in diverse eye diseases are explored. Finally, the current challenges affecting research in this field are outlined to provide a basis that guide future utilization of sEVs miRNAs in ophthalmic disease research and clinical management of diverse ophthalmological conditions.

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sev mirna的眼部景观分析：机制和应用

本文从sev mirna的基本特征和临床应用潜力等方面综述了sev mirna在眼科疾病中的应用。首先，我们概述了sev，包括它们的定义、来源和功能，同时特别强调了sev中包含的mirna的重要性及其在眼部疾病治疗中的前景。随后，sev的结构和组成及其被封装的mirna的生物学功能，扩大了目前对其在眼科生理和病理中的作用的认识。此外，还讨论了sev mirna在眼组织生长、眼组织稳态和常见眼病（如青光眼、年龄相关性黄斑变性和糖尿病视网膜病变）中的功能。探讨了sev mirna作为眼科疾病的诊断生物标志物和药物传递系统的应用潜力以及在多种眼病中的治疗价值。最后，概述了当前影响该领域研究的挑战，为指导未来sev mirna在眼科疾病研究和各种眼科疾病的临床管理中的应用提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental eye research 医学-眼科学

CiteScore

6.80

自引率

5.90%

发文量

323

审稿时长

66 days

期刊介绍： The primary goal of Experimental Eye Research is to publish original research papers on all aspects of experimental biology of the eye and ocular tissues that seek to define the mechanisms of normal function and/or disease. Studies of ocular tissues that encompass the disciplines of cell biology, developmental biology, genetics, molecular biology, physiology, biochemistry, biophysics, immunology or microbiology are most welcomed. Manuscripts that are purely clinical or in a surgical area of ophthalmology are not appropriate for submission to Experimental Eye Research and if received will be returned without review.