BBr3-Mediated ortho C–H Borylation of Benzamides

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-25 DOI:10.1021/acs.orglett.5c00822

Yixuan Liang, Chengyu Du, Chengwen Dong, Jinxi Cao, Yijia Xu, Hua Zhang

引用次数: 0

Abstract

We have developed a BBr₃-mediated, metal-free ortho C–H borylation of benzamides, enabling the synthesis of a wide range of ortho-borylated benzamides in moderate to good yields. This transformation offers a convenient strategy for accessing functionalized benzamides, which are valuable intermediates in pharmaceuticals, agrochemicals, and fine chemical synthesis.

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bbr3介导的苯酰胺邻位C-H硼化反应

我们已经开发了一种bbr3介导的，无金属的邻位C-H苯酰化苯酰胺，能够以中等到较高的收率合成各种邻位硼酰化苯酰胺。这种转化为获得功能化苯酰胺提供了一种方便的策略，苯酰胺是药物、农用化学品和精细化学合成中有价值的中间体。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.