Cobalt-Catalyzed Regioselective Intramolecular Hydrosilylation of Olefins to Access Sila-heterocycles

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-25 DOI:10.1021/acs.orglett.5c01071

Teng-Teng Wu, Zi-Lu Wang, Yun-He Xu

引用次数: 0

Abstract

An efficient and straightforward cobalt-catalyzed regioselective intramolecular hydrosilylation of olefins has been developed. Regioselectivity is controlled by the choice of ligands and substrates, which operate through two distinct mechanisms. This method has been successfully applied to both terminal and internal alkenes and phenyl and alkyl tethers between the silane and the alkene, demonstrating its versatility across a broad range of substrates.

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钴催化烯烃分子内区域选择性硅氢化反应制备硅杂环

我们开发出了一种高效、简便的钴催化烯烃分子内区域选择性氢硅烷化反应。区域选择性由配体和底物的选择控制，配体和底物通过两种不同的机制起作用。该方法已成功应用于端烯烃和内烯烃，以及硅烷和烯烃之间的苯基和烷基三元组，证明了它在多种底物上的通用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.