Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-24 DOI:10.1021/acs.orglett.5c00899

Bo-Xi Liu, Syed Anis Ali Shah, Feng Zhou, Weidong Rao, Shu-Su Shen, Daopeng Sheng, Shun-Yi Wang

引用次数: 0

Abstract

A visible-light-induced trifunctionalization of unactivated alkenes for building functionalized oxindoles through a radical cyano migration strategy is reported. This transformation employs a tandem alkene sulfonylation-initiated cyano migration/cyclization cascade process. This strategy features stable and easily accessible substrates, mild reaction conditions, metal-free catalysts, and the capability of late-stage functionalization.

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基于氰基迁移和环化中继策略的功能化氧吲哚构建

本文报道了一种可见光诱导的非活化烯烃三功能化方法，通过自由基氰基迁移策略来构建功能化的氧吲哚。该转化采用串联烯烃磺酰化引发氰基迁移/环化级联过程。该策略具有稳定和易于获取的底物，温和的反应条件，无金属催化剂和后期功能化能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.