Photoenzymatically-Induced Asymmetric Hydroarylation of Alkenes with (Hetero)aryl Halides

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-25 DOI:10.1039/d5cc00617a

Corey L Jones, Alandra Quinn, Xiaochun Alex Wang, Jason K. Smith, Jeffrey Casavant, Simon Berritt, Thomas Knauber, Carlos Martinez, Jovan Livada, Scott P. France, Paul Richardson, Roger Howard, Hatice Gizem Yayla

引用次数: 0

Abstract

A set of stereocomplementary ene-reductase enzymes are described which, when induced by light and aided by an exogenous photocatalyst, catalyze the coupling of (hetero)aryl halides and alkenes in an asymmetric intermolecular hydroarylation process. Thus, carbon scaffolds containing C(sp²)-C(sp³) bonds are synthesized enzymatically from simple precursors in excellent enantiomeric excess. Furthermore, an intramolecular mode is presented with improved yield.

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光酶诱导烯烃与（杂）芳基卤化物的不对称氢芳基化反应

描述了一组立体互补烯还原酶，当光诱导和外源光催化剂的辅助下，催化（杂）芳基卤化物和烯烃在不对称分子间氢芳基化过程中的偶联。因此，含有C(sp2)-C（sp3）键的碳支架是由简单的前体以优异的对映体过量酶促合成的。此外，还提出了一种提高收率的分子内模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.