Tumor Microenvironment On-A-Chip and Single-Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression (Adv. Sci. 16/2025)

Abstract

Tumor on-a-Chip

This image depicts a cutting-edge 3D tumor-on-a-chip model that recapitulates the breast tumor microenvironment, highlighting interactions between stromal, immune, and metastatic triplenegative breast cancer cells. By mimicking tumor-stroma-immune crosstalk, this model reveals cancer cell metabolic reprogramming through bioinformatic analysis. This innovative platform advances the understanding of tumor biology, providing insights into cellular adaptations and potential therapeutic targets. More details can be found in article number 2413457 by Mehdi Nikkhah, and co-workers. Create with BioRender.com.