Precision Control of Cell Type-Specific Behavior via RNA Sensing and Editing (Small Methods 4/2025)

IF 10.7 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Small Methods Pub Date : 2025-04-24 DOI:10.1002/smtd.202570028

Lulu Xiao, Bo Qin, Xinyue Zhang, Yufeng Yao, Xiaoyan Dou, Yuchen Liu, Xuanchu Duan

引用次数: 0

Abstract

Inside Back Cover

In article number 2400952, Dou, Liu, Duan, and co-workers introduce the innovative CRISPR-ADAReader system, which enables precise manipulation of cell activity through the detection and modification of endogenous RNA. Featuring both positive and negative feedback loops, the system allows for tailored regulation across different cell types in response to various internal signals, showcasing exceptional programmability, specificity, and sensitivity.

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通过RNA传感和编辑精确控制细胞类型特异性行为（Small Methods 4/2025）

在2400952号文章中，窦、刘、段和同事介绍了创新的CRISPR-ADAReader系统，该系统可以通过检测和修饰内源性RNA来精确操纵细胞活性。该系统具有正负反馈回路，可根据不同的内部信号对不同的细胞类型进行量身定制的调节，具有卓越的可编程性、特异性和敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small Methods Materials Science-General Materials Science

CiteScore

17.40

自引率

1.60%

发文量

347

期刊介绍： Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.