Rapid High-Throughput Discovery of Molecules With Antimicrobial Activity From Natural Products Enabled by a Nanoliter Matrix SlipChip (Small Methods 4/2025)

Abstract

Novel Antibiotics

The nm-SlipChip creates a screening matrix using nanoliter droplets to test 100 drug candidate-bacterium combinations, evaluating antibiotic effectiveness based on phenotypic changes in microorganisms. It reduces sample consumption by more than 5000-fold and shortens detection time to approximately three hours. Using this nm-SlipChip, we identified two new clerodane diterpenes from Callicarpa integerrima that inhibit MRSA. More in article number 2402045, Tao, Xiao, Shen and co-workers.