TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-04-23 DOI:10.1083/jcb.202503004

Yu Sun,Terytty Yang Li

引用次数: 0

Abstract

Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging.

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TMBIM-2通过钙信号将神经元线粒体应激与系统适应联系起来。

线粒体功能对神经元活动和全身代谢适应至关重要。在这期杂志上，Li等人（https://doi.org/10.1083/jcb.202408050）发现TMBIM-2是钙动力学的关键调节因子，协调神经元到肠道线粒体未折叠蛋白反应（UPRmt）、病原体诱导的厌恶学习和衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.