A plant dual-kinase protein traps a pathogen effector to trigger immunity

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-04-23 DOI:10.1038/s41588-025-02176-4

引用次数: 0

Abstract

Tandem kinase proteins (TKPs) are key regulators of plant immunity. We found that RWT4, a wheat TKP, confers resistance to the fungal pathogen Magnaporthe oryzae by directly recognizing the effector AvrPWT4. Recognition of AvrPWT4 depends on the RWT4 N-terminal partial kinase duplication region, which is essential for pathogen perception and defense activation.

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植物双激酶蛋白捕获病原体效应物以触发免疫

串联激酶蛋白（TKPs）是植物免疫的关键调控因子。我们发现，小麦TKP RWT4通过直接识别效应物AvrPWT4而对真菌病原体产生抗性。AvrPWT4的识别依赖于RWT4 n端部分激酶重复区域，该区域对病原体感知和防御激活至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution