Total Synthesis and Stereochemical Assignment of Cubensci Acid

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-04-23 DOI:10.1039/d5qo00545k

Yangyang Jiang, Junyang LIU, Tao Ye

引用次数: 0

Abstract

The absolute configuration of cubensic acid was predicted using the “Biochemistry-based Rule” and confirmed through total synthesis. Key steps in the synthesis included a titanium-mediated aldol reaction, a Paterson anti-aldol reaction, and a vinylogous Mukaiyama aldol reaction.

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古bensci酸的全合成及立体化学配位

利用“生物化学规则”预测了立方酸的绝对构型，并通过全合成进行了确定。合成的关键步骤包括钛介导的醛醇反应、Paterson抗醛醇反应和葡萄状的Mukaiyama醛醇反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.