Bioengineered Versatile Heterojunctions as Stress Busters Targeting Matrix Degradation and Ferroptosis for Osteoarthritis Therapy (Adv. Funct. Mater. 16/2025)

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Functional Materials Pub Date : 2025-04-23 DOI:10.1002/adfm.202570094

Zhao Zhang, Debin Cheng, Dong Liu, Jingyi Dang, Xiaohe Wang, Hong Wu, Hongbin Fan

引用次数: 0

Abstract

Bioengineered Versatile Heterojunctions

In article number 2419400, Hongbin Fan and co-workers showcase bioengineered versatile heterojunctions consisting of MPN and 2D MBene. The bio-heterojunctions have excellent enzyme mimicking, cartilage-targeting, and responsive releasing properties for the treatment of osteoarthritis. Mechanistically, the bio-heterojunction can block the Perk-eIF2α mediated integrated stress response to prevent cartilage matrix degradation and ferroptosis.

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生物工程多功能异质结作为靶向基质降解和铁下垂的应激抑制剂用于骨关节炎治疗。板牙。16/2025)

生物工程多功能异质结在第 2419400 号文章中，范洪斌及其合作者展示了由 MPN 和二维 MBene 组成的生物工程多功能异质结。这种生物异质结具有优异的酶模拟、软骨靶向和响应释放特性，可用于治疗骨关节炎。从机理上讲，生物异质结可以阻断 Perk-eIF2α 介导的综合应激反应，从而防止软骨基质降解和铁变态反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.