Anti-inflammatory and anti-diabetic activity of N1-(4-substitutedbenzyl)/Butyl-2-methyl-4-nitro-3-imidazolium (E)-3-(4-hydroxy-3-methoxyphenyl)acrylates

Journal of Ionic Liquids Pub Date : 2025-03-26 DOI:10.1016/j.jil.2025.100148

Dhurairaj Satheesh , Annamalai Rajendran , Chandrasekran Geetha , Krishnan Parthipan , Ayyandurai Thirunavukkarasu , Karunanithi Suganya

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Abstract

A series of nine N¹-(4-substitutedbenzyl/butyl)-2-methyl-4-nitro-1H-imidazoles (3a-i) and their N¹-(4-substitutedbenzyl)/Butyl-2-methyl-4-nitro-3-imidazolium (E)-3-(4-hydroxy-3-methoxyphenyl)acrylates (IMS-19, 21-27) were screened for their anti-inflammatory and anti-diabetic activity in different concentrations (20, 40, 80, 200 & 400 μg/mL). The Diclofenac sodium and Acarbose were used as standard drugs for anti-inflammatory and anti-diabetic activities respectively. The 4-nitro-1H-imidazoles (3a-i) and their protic imidazolium salts with (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate as an organic anion (IMS-19, 21-27) are showed very good to remarkable anti-inflammatory and good to excellent anti-diabetic activities compared to their corresponding standard drug.

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N1-（4-取代苄基）/丁基-2-甲基-4-硝基-3-咪唑(E)-3-（4-羟基-3-甲氧基苯基）丙烯酸酯的抗炎和抗糖尿病活性

筛选了9个N1-（4-取代苄基/丁基）-2-甲基-4-硝基- 1h -咪唑（3a-i）及其N1-（4-取代苄基）/丁基-2-甲基-4-硝基-3-咪唑(E)-3-（4-羟基-3-甲氧基苯基）丙烯酸酯（ims - 19,21 -27）在不同浓度(20、40、80、200和amp；400μg / mL)。双氯芬酸钠和阿卡波糖分别作为抗炎和抗糖尿病的标准药物。与相应的标准药物相比，以(E)-3-（4-羟基-3-甲氧基苯基）丙烯酸酯为有机阴离子的4-硝基- 1h -咪唑类（3a-i）及其质子咪唑类盐（ims - 19,21 -27）具有很好的抗炎和抗糖尿病活性。

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来源期刊

Journal of Ionic Liquids

CiteScore

3.70

自引率

0.00%

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