Particulate platform for pulmonary drug delivery: Recent advances of formulation and fabricating strategies

IF 5.3 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics Pub Date : 2025-04-17 DOI:10.1016/j.ijpharm.2025.125601

Zijia Zhang, Mengya Jin, Xinyu Yang, Heng Zhu, Huijie Li, Qingliang Yang

{"title":"Particulate platform for pulmonary drug delivery: Recent advances of formulation and fabricating strategies","authors":"Zijia Zhang, Mengya Jin, Xinyu Yang, Heng Zhu, Huijie Li, Qingliang Yang","doi":"10.1016/j.ijpharm.2025.125601","DOIUrl":null,"url":null,"abstract":"<div><div>Pulmonary drug delivery for managing respiratory diseases has attained a significant maturity level and holds substantial potential for applications in treating systemic diseases. Advancements in pulmonary delivery techniques have driven the innovative development of dry powder inhalers (DPIs), specifically engineered to optimize the efficacy of pulmonary drug delivery. This review examines recent progress in formulation and manufacturing strategies of inhalable dry powder, focusing on prescription design and fabrication approaches for advanced particulate systems. These include the integration of cutting-edge excipients into conventional formulations, nano-based delivery system, composite particles, and a blend of traditional and next-generation processing techniques, all contributing to enhanced drug delivery efficiency and bioavailability. Additionally, this review discusses the latest advancements in DPI devices. This review aims to provide a clear perspective on emerging inhalable dry powder formulation and processing trends for pulmonary delivery, highlighting the critical role of novel particulate platform in advancing pulmonary drug delivery systems.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"676 ","pages":"Article 125601"},"PeriodicalIF":5.3000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378517325004387","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Pulmonary drug delivery for managing respiratory diseases has attained a significant maturity level and holds substantial potential for applications in treating systemic diseases. Advancements in pulmonary delivery techniques have driven the innovative development of dry powder inhalers (DPIs), specifically engineered to optimize the efficacy of pulmonary drug delivery. This review examines recent progress in formulation and manufacturing strategies of inhalable dry powder, focusing on prescription design and fabrication approaches for advanced particulate systems. These include the integration of cutting-edge excipients into conventional formulations, nano-based delivery system, composite particles, and a blend of traditional and next-generation processing techniques, all contributing to enhanced drug delivery efficiency and bioavailability. Additionally, this review discusses the latest advancements in DPI devices. This review aims to provide a clear perspective on emerging inhalable dry powder formulation and processing trends for pulmonary delivery, highlighting the critical role of novel particulate platform in advancing pulmonary drug delivery systems.

Abstract Image

查看原文本刊更多论文

肺给药微粒平台：配方和制造策略的最新进展

肺给药治疗呼吸系统疾病已经达到了显著的成熟水平，在治疗全身性疾病方面具有巨大的应用潜力。肺给药技术的进步推动了干粉吸入器（dpi）的创新发展，专门设计用于优化肺给药的疗效。本文综述了可吸入干粉的配方和制造策略的最新进展，重点是先进颗粒系统的处方设计和制造方法。这些包括将尖端赋形剂整合到传统配方、纳米基给药系统、复合颗粒以及传统和下一代加工技术的混合，所有这些都有助于提高药物给药效率和生物利用度。此外，本文还讨论了DPI设备的最新进展。这篇综述旨在为肺部给药的可吸入干粉配方和加工趋势提供一个清晰的视角，强调新型颗粒平台在推进肺部给药系统中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Pharmaceutics 医学-药学

CiteScore

10.70

自引率

8.60%

发文量

951

审稿时长

72 days

期刊介绍： The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.