Mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction according to body weight

IF 16.9 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

European Journal of Heart Failure Pub Date : 2025-04-21 DOI:10.1002/ejhf.3665

Jawad H. Butt, Scott D. Solomon, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Lars Køber, Bertram Pitt, Faiez Zannad, Pardeep S. Jhund, John J.V McMurray

引用次数: 0

Abstract

Obesity is associated with excessive adipocyte-derived aldosterone secretion, independent of the classical renin–angiotensin–aldosterone cascade, and mineralocorticoid receptor antagonists (MRAs) may be more effective in obese patients with heart failure (HF) with reduced ejection fraction (HFrEF).

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矿质皮质激素受体拮抗剂在心力衰竭与降低射血分数根据体重

肥胖与脂肪细胞衍生的醛固酮分泌过多有关，独立于经典的肾素-血管紧张素-醛固酮级联反应，而矿皮质激素受体拮抗剂（MRAs）可能对伴有射血分数（HFrEF）降低的心力衰竭（HF）的肥胖患者更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Heart Failure 医学-心血管系统

CiteScore

27.30

自引率

11.50%

发文量

365

审稿时长

1 months

期刊介绍： European Journal of Heart Failure is an international journal dedicated to advancing knowledge in the field of heart failure management. The journal publishes reviews and editorials aimed at improving understanding, prevention, investigation, and treatment of heart failure. It covers various disciplines such as molecular and cellular biology, pathology, physiology, electrophysiology, pharmacology, clinical sciences, social sciences, and population sciences. The journal welcomes submissions of manuscripts on basic, clinical, and population sciences, as well as original contributions on nursing, care of the elderly, primary care, health economics, and other related specialist fields. It is published monthly and has a readership that includes cardiologists, emergency room physicians, intensivists, internists, general physicians, cardiac nurses, diabetologists, epidemiologists, basic scientists focusing on cardiovascular research, and those working in rehabilitation. The journal is abstracted and indexed in various databases such as Academic Search, Embase, MEDLINE/PubMed, and Science Citation Index.