Concordance of dengue viral load with disease severity and different clinical manifestations: A systematic review and meta-analysis

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2025-04-15 DOI:10.1016/j.ijmmb.2025.100852

Diksha Mohapatra , Baijayantimala Mishra , Prabhudutta Mamidi , Sailendra Panda

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引用次数: 0

Abstract

Introduction

Dengue is a common arboviral disease of tropical and sub-tropical regions of the globe with high prevalence rate in South-East Asian region. Association of viral load with dengue disease severity is dependent on various factors like dengue serotype, primary or secondary infection and immune response of an individual. The objective of the study was to evaluate the association of dengue viral load with dengue disease severity like dengue fever (DF), dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS), dengue serotypes and different clinical manifestations detected during dengue like thrombocytopenia, leukopenia and increased liver enzymes.

Materials and methods

The systematic review and meta-analysis [PROSPERO (CRD42024601682)] is prepared by abiding to PRISMA checklist. It includes twenty-nine observational cross-sectional studies, which has compared association of dengue viral load with dengue disease severity, dengue serotypes and different clinical manifestations in dengue patients.

Result

A total of 3983 dengue patients were included in the studies out of which 1758 were diagnosed with DF and 2225 were diagnosed with DHF/DSS. Most of the studies were from South-East Asian countries followed by America and Europe. Meta-analysis of the studies revealed that, high viral load was mostly detected in DHF/DSS as compared to DF. Regarding co-relation of viral load, chances of high viral load was more in female patients than male patients. On comparing viral load with different clinical manifestations, it was seen that, the odds of high viral load were more in patients diagnosed with thrombocytopenia and leukopenia, whereas the odds of high viral load were lower in patients diagnosed with increased secretion of liver enzymes.

Conclusion

High Viral load had significant association with dengue disease severity. Female patients had high viral load as compared to male patients. Therefore, viral load may be regarded a potential prognostic tool in detecting dengue severity in patients, and studies need to be conducted with sufficient sample size, abiding to a single classification system and measure of outcome to prevent heterogeneity.

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登革热病毒载量与疾病严重程度和不同临床表现的一致性：一项系统回顾和荟萃分析

登革热是全球热带和亚热带地区常见的一种虫媒病毒性疾病，在东南亚地区发病率较高。病毒载量与登革热严重程度的关联取决于多种因素，如登革热血清型、原发性或继发性感染以及个体的免疫反应。该研究的目的是评估登革热病毒载量与登革热疾病严重程度的关系，如登革热（DF）、登革热出血热/登革热休克综合征（DHF/DSS）、登革热血清型和登革热期间检测到的不同临床表现，如血小板减少症、白细胞减少症和肝酶升高。材料和方法系统评价和荟萃分析[PROSPERO (CRD42024601682)]按照PRISMA核对表进行准备。它包括29项观察性横断面研究，这些研究比较了登革热病毒载量与登革热疾病严重程度、登革热血清型和登革热患者不同临床表现的关系。结果共纳入3983例登革热患者，其中DF诊断为1758例，DHF/DSS诊断为2225例。大多数研究来自东南亚国家，其次是美国和欧洲。研究荟萃分析显示，与DF相比，DHF/DSS中大多数检测到高病毒载量。在病毒载量的相关性方面，女性患者出现高病毒载量的几率高于男性患者。比较不同临床表现的病毒载量，发现诊断为血小板减少症和白细胞减少症的患者出现高病毒载量的几率较大，而诊断为肝酶分泌增高的患者出现高病毒载量的几率较小。结论高病毒载量与登革热严重程度有显著相关性。与男性患者相比，女性患者的病毒载量较高。因此，病毒载量可能被视为检测患者登革热严重程度的潜在预后工具，研究需要在足够的样本量下进行，遵守单一的分类系统和结果测量以防止异质性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.