Mind the messenger: role of extracellular vesicle signalling in postoperative neurocognitive dysfunction.

IF 9.1 1区医学 Q1 ANESTHESIOLOGY

British journal of anaesthesia Pub Date : 2025-04-17 DOI:10.1016/j.bja.2025.03.003

Samarjit Das,Michael J Devinney,Miles Berger,Charles H Brown

引用次数: 0

Abstract

Extracellular vesicles are secreted by virtually every cell and allow the transfer of bioactive molecules including proteins, nucleic acids, and lipids to other cell types across the body. This study of the role of extracellular vesicles and their cargo in postoperative cognitive dysfunction after hip or knee replacement surgery reports differential protein and microRNA expression in patients with postoperative cognitive decline versus improvement. This small study in a select surgical population highlights the potential for extracellular vesicles and their contents to play a signalling role in postoperative neurocognitive disorders.

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注意信使：细胞外囊泡信号在术后神经认知功能障碍中的作用。

细胞外囊泡几乎由每个细胞分泌，可将蛋白质、核酸和脂质等生物活性分子转移到全身其他类型的细胞中。这项关于细胞外囊泡及其载体在髋关节或膝关节置换手术后认知功能障碍中的作用的研究报告显示，在术后认知功能下降与改善的患者中，蛋白质和 microRNA 的表达存在差异。这项针对特定手术人群的小型研究强调了细胞外囊泡及其内容物在术后神经认知障碍中发挥信号作用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British journal of anaesthesia 医学-麻醉学

CiteScore

13.50

自引率

7.10%

发文量

488

审稿时长

27 days

期刊介绍： The British Journal of Anaesthesia (BJA) is a prestigious publication that covers a wide range of topics in anaesthesia, critical care medicine, pain medicine, and perioperative medicine. It aims to disseminate high-impact original research, spanning fundamental, translational, and clinical sciences, as well as clinical practice, technology, education, and training. Additionally, the journal features review articles, notable case reports, correspondence, and special articles that appeal to a broader audience. The BJA is proudly associated with The Royal College of Anaesthetists, The College of Anaesthesiologists of Ireland, and The Hong Kong College of Anaesthesiologists. This partnership provides members of these esteemed institutions with access to not only the BJA but also its sister publication, BJA Education. It is essential to note that both journals maintain their editorial independence. Overall, the BJA offers a diverse and comprehensive platform for anaesthetists, critical care physicians, pain specialists, and perioperative medicine practitioners to contribute and stay updated with the latest advancements in their respective fields.