Recently Discovered Heteromeric Enzymes in Natural Product Biosynthesis.

IF 4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biological Chemistry Pub Date : 2025-04-15 DOI:10.1016/j.jbc.2025.108516

Zhongtian Yu,Ikuro Abe

引用次数: 0

Abstract

The abundant diversity and elegant complexity in the chemical structures of natural products have attracted vigorous investigations of the chemistry and enzymology underlying their biosynthetic processes over the past few decades. Among the biochemical events, the formation of complexes of heteromeric enzymes has been observed in the biosynthesis of several natural products and metabolic pathways. In this review, we aim to consolidate the recently discovered cases of heteromeric enzymes in natural product biosynthesis and metabolism, in order to clarify the genetic and structural bases leading to the formation of these heteromeric complexes and provide insights for the rational redesign of proteins in biosynthetic machineries.

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天然产物生物合成中新发现的异聚酶。

在过去的几十年里，天然产物化学结构的丰富多样性和优雅的复杂性吸引了人们对其生物合成过程背后的化学和酶学的积极研究。在生物化学事件中，异质酶复合物的形成已在几种天然产物的生物合成和代谢途径中被观察到。本文综述了近年来在天然产物生物合成和代谢中发现的异质酶，旨在阐明这些异质复合物形成的遗传和结构基础，为生物合成机制中蛋白质的合理设计提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biological Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

自引率

4.20%

发文量

1233

期刊介绍： The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.