Minimum inhibitory concentration of penicillin as a surrogate for in vitro piperacillin susceptibility of ampicillin-susceptible Enterococcus faecalis

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-04-14 DOI:10.1016/j.diagmicrobio.2025.116850

Kohei Hasegawa , Kumiko Suzuki , Kenya Murata , Yoshihiko Ogawa

引用次数: 0

Abstract

This study evaluated whether penicillin MICs can predict piperacillin susceptibility in Enterococcus faecalis. Among 427 strains, 10 were resistant to piperacillin. Even strains with penicillin MICs of 4-8 µg/mL may exhibit resistance. These findings suggest that even penicillin MICs within the susceptible range may indicate piperacillin resistance, challenging CLSI guidelines.

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青霉素的最低抑菌浓度作为氨苄西林敏感粪肠球菌体外哌拉西林敏感性的替代物

本研究评估了青霉素 MIC 是否能预测粪肠球菌对哌拉西林的敏感性。在 427 株菌株中，有 10 株对哌拉西林产生耐药性。即使青霉素 MIC 值为 4-8 µg/mL 的菌株也可能表现出耐药性。这些研究结果表明，即使青霉素 MIC 值在易感范围内，也可能显示出对哌拉西林的耐药性，这对 CLSI 的指导方针提出了挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.