Chemical constituents and anti-inflammatory investigation of Elsholtzia rugulosa Hemsl

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-17 DOI:10.1016/j.fitote.2025.106550

Xue-Ying Xu , Qiong Jin , Jia-Mei Geng, Pei-Feng Zhu, Zhu-Ya Yang, Xin Duan, Lu Liu

引用次数: 0

Abstract

Two undescribed furan derivatives elsholtzia ketone-9-O-β-glucopyranoside (1) and 8-hydroxy-elsholtzia ketone-9-O-β-glucopyranoside (2) along with ten known compounds (3−12), were isolated from Elsholtzia rugulosa Hemsl. Their structures were elucidated based on extensive analyses of spectroscopic data and quantum chemical calculations. Anti-inflammatory experiments showed that 1, 7, and 12 reduce the production of nitric oxide (NO) and the levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in RAW264.7 cells.

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黑草的化学成分及抗炎研究

从芦笋中分离得到两个未描述的呋喃衍生物elsholtzia酮-9- o -β-葡萄糖苷(1)和8-羟基elsholtzia酮-9- o -β-葡萄糖苷(2)以及10个已知化合物（3−12）。它们的结构是基于光谱数据和量子化学计算的广泛分析来阐明的。抗炎实验表明，1、7和12可降低RAW264.7细胞一氧化氮（NO）的生成，降低脂多糖（LPS）诱导的肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β)和白细胞介素-6 （IL-6）的水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.