Cavernous sinus syndrome in a patient with occult nasopharyngeal carcinoma: A diagnostic challenge

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-04-18 DOI:10.1016/j.oraloncology.2025.107316

Ping Zhou , Yingming Zhu , Baolei Xu , Xiao Jiang , Wei Wang , Ye Zhang

引用次数: 0

Abstract

Nasopharyngeal carcinoma(NPC) is an epithelial malignancy of the nasopharyngeal mucosa. It typically exhibits local infiltration with frequent skull base involvement and often presents with multiple cranial neuropathies. It can invade the cavernous sinus via the skull base and foramen ovals, thereby causing cavernous sinus syndrome (CSS). When NPC invades nerves, the mass in the nasopharyngeal cavity may not be obvious. We report a case of CSS presenting as painful ophthalmoplegia or nonspecific inflammation. While initial glucocorticoid therapy provided transient symptom relief, the patient developed progressive neurological deficits. Ultimately, nasopharyngoscopic biopsy confirmed NPC through histopathological verification.

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隐匿性鼻咽癌患者的海绵窦综合征：一个诊断挑战

鼻咽癌（NPC）是一种鼻咽粘膜上皮性恶性肿瘤。它通常表现为局部浸润，经常累及颅底，并常表现为多发性颅神经病变。可经颅底及卵圆孔侵入海绵窦，引起海绵窦综合征。当鼻咽癌侵犯神经时，鼻咽腔内肿块可能不明显。我们报告一例CSS表现为疼痛性眼麻痹或非特异性炎症。虽然最初的糖皮质激素治疗提供了短暂的症状缓解，但患者出现了进行性神经功能障碍。最终，鼻咽镜活检经组织病理学证实为鼻咽癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.