Risk factors for peripheral arterial disease in type 2 diabetes mellitus patients: A systematic review and meta-analysis

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-04-10 DOI:10.1016/j.diabres.2025.112170

Martha Rosana , Em Yunir , Ninik Saragih , Lusiani Rusdi , Dyah Purnamasari , Tri Juli Edi Tarigan , Dicky Levenus Tahapary , Pradana Soewondo

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引用次数: 0

Abstract

Background

Peripheral arterial disease (PAD) is a complication of type 2 diabetes mellitus (T2DM). No systematic review and meta-analysis has been conducted regarding the risk factors of PAD in T2DM populations.

Aim

To analyze the pooled effect estimates of risk factors of PAD in T2DM populations.

Methods

A systematic literature search was conducted in PubMed/MEDLINE, ProQuest, and EMBASE databases. The Newcastle-Ottawa Scale was used to assess the risk of bias. Meta-analysis was performed using RevMan version 5.4.

Results

Ten studies were included in this review (73,834 samples in total). All the studies had a low risk of bias. Significant association with PAD in T2DM was found in the group of age ≥ 70 years old (OR 3.44; 95 % CI 2.11, 5.62), diabetes duration ≥ 5 years (OR 1.81; 95 % CI 1.24, 2.64), coronary artery disease (CAD) history (OR 1.55; 95 % CI 1.30, 1.83), hypertension (OR 1.43; 95 % CI 1.10, 1.86), and increased LDL (OR 2.51; 95 % CI 1.38, 4.56).

Conclusion

Age ≥ 70 years old, diabetes duration ≥ 5 years, CAD history, hypertension, and increased LDL are significant risk factors for PAD in the T2DM population.

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2型糖尿病患者外周动脉疾病的危险因素：系统回顾和荟萃分析

外周动脉疾病（PAD）是2型糖尿病（T2DM）的一种并发症。目前还没有关于2型糖尿病人群PAD危险因素的系统综述和荟萃分析。目的分析T2DM人群PAD危险因素的综合效应估计。方法系统检索PubMed/MEDLINE、ProQuest、EMBASE数据库的文献。纽卡斯尔-渥太华量表用于评估偏倚风险。meta分析采用RevMan version 5.4进行。结果共纳入10项研究（73834份样本）。所有研究的偏倚风险都很低。年龄≥70岁的T2DM患者与PAD有显著相关性(OR 3.44；95% CI 2.11, 5.62)，糖尿病病程≥5年(OR 1.81；95% CI 1.24, 2.64)，冠状动脉疾病（CAD）病史(OR 1.55；95% CI 1.30, 1.83)，高血压(OR 1.43；95% CI 1.10, 1.86)， LDL升高(OR 2.51；95% ci 1.38, 4.56)。结论年龄≥70岁、糖尿病病程≥5年、冠心病史、高血压、LDL升高是T2DM人群发生PAD的重要危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.