Visible-Light Promoted Iron-Catalyzed C–C Bond Cleavage of 1,2-Diols to Carbonyls

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-04 DOI:10.1021/acs.orglett.4c0481610.1021/acs.orglett.4c04816

Chunyan Shu, Jing Wang, Junying Song, Yiwen Ouyang, Jin-Bu Xu, Feng Gao* and Xiaohuan Li*,

引用次数: 0

Abstract

A simple visible-light-promoted iron-catalyzed aerobic oxidative C–C bond cleavage of vicinal diols was developed. This reaction avoids the use of noble metal catalysts or specialized oxidants, yielding aldehydes and ketones without overoxidation. The new method works under air and at room temperature and features mild conditions and simple operation. Notably, the protocol is applicable for complex natural products, achieving the bioinspired conversion of the natural abundant diterpene oridonin to the natural rare enmein-type diterpene.

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可见光促进铁催化的1,2-二醇C-C键裂解成羰基

研究了一种简单的可见光催化铁氧化邻二醇C-C键裂解反应。该反应避免使用贵金属催化剂或专门的氧化剂，生成醛和酮而不会过度氧化。新方法在空气和室温下工作，条件温和，操作简单。值得注意的是，该方案适用于复杂的天然产物，实现了天然丰富的二萜oriidonin向天然稀有的enmein型二萜的生物转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.