Maternal Tmprss6 is required for hepcidin suppression and fetal health.

IF 21 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2025-04-15 DOI:10.1182/blood.2024027563

Katherine Louise Fielding,Cavan Bennett,Anne Pettikiriarachchi,Naomi Jones,Rebecca Harding,Alistair R D McLean,Louise M Randall,Ute Schaeper,Alberto Martinez,Ricardo Ataide,Sant-Rayn Pasricha

引用次数: 0

Abstract

The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated as knockout dams are infertile. Utilising an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.

查看原文本刊更多论文

母体Tmprss6是抑制hepcidin和胎儿健康所必需的。

hepcatin调节蛋白酶Tmprss6的产前作用从未被阐明，因为敲除小鼠是不育的。利用体内敲低方法，我们证实Tmprss6对妊娠期hepcidin抑制至关重要，并且Tmprss6抑制会导致有害的胎儿结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.