{"title":"Cancer vaccines: the experts speak","authors":"Iris Marchal","doi":"10.1038/s41587-025-02606-y","DOIUrl":null,"url":null,"abstract":"The development of therapeutic cancer vaccines has long been a promising yet challenging field of research. While early efforts were impeded by limited efficacy and immune escape, recent advances in immunotherapy, mRNA technology and tumor antigen discovery have sparked renewed interest in cancer vaccine development. What is the current state of the field, and how should we address the remaining challenges to bring therapeutic cancer vaccines to the clinic? Which modalities hold potential, and what might the future of therapeutic cancer vaccines look like?","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"113 1","pages":""},"PeriodicalIF":33.1000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1038/s41587-025-02606-y","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The development of therapeutic cancer vaccines has long been a promising yet challenging field of research. While early efforts were impeded by limited efficacy and immune escape, recent advances in immunotherapy, mRNA technology and tumor antigen discovery have sparked renewed interest in cancer vaccine development. What is the current state of the field, and how should we address the remaining challenges to bring therapeutic cancer vaccines to the clinic? Which modalities hold potential, and what might the future of therapeutic cancer vaccines look like?
期刊介绍:
Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research.
The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field.
Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology.
In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.