Tailored Therapeutic Approach in a Patient With Diffuse Large B-Cell Lymphoma With Meningeal Infiltration, Concurrent Classic Hodgkin Lymphoma, and Smoldering Multiple Myeloma: A Case Report

IF 1.5 Q4 ONCOLOGY

Cancer reports Pub Date : 2025-04-15 DOI:10.1002/cnr2.70102

Giusy Ceparano, Daniele Lorenzini, Maurilio Ponzoni, Giorgia Levati, Davide Epifania, Vincenzo Marasco

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Abstract

Background

Coexisting primary hematologic malignancies in untreated multiple myeloma (MM) are rare.

Case

A 69-year-old man with smoldering multiple myeloma (sMM) presented with lymphadenopathies and an intracranial mass. He was diagnosed with diffuse large B-cell lymphoma (DLBCL), classic Hodgkin lymphoma (cHL), and sMM. The patient received R-CHOP and R-ICE, followed by autologous stem cell transplantation, achieving complete remission of DLBCL and cHL, and very good partial remission of MM.