Two Pyridine Alkaloids from Portulaca oleracea and their Anti-Inflammatory and Antioxidant Activities

Abstract

Two pyridine alkaloids, 5-ethoxypyridin-2-ol, named olerapyridineol (1) and methyl 5-hydroxynicotinate (2), were obtained from the Portulaca oleracea L., from which compound 1 was the new compound and compound 2 was isolated from P. oleracea for the first time. The structure of compound 1 was identified by UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR. Compounds 1–2 presented antioxidant activities with IC₅₀ values of 42.625 ± 0.37, 37.423 ± 0.43 μM. In addition, the anti-inflammatory effects on lipopolysaccharide-stimulated macrophages of compounds 1–2 were also investigated.