Advances in transition metal-catalyzed hydroamination of strained ring systems: A comprehensive review

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-05 DOI:10.1016/j.tet.2025.134652

Anns Maria Thomas , Amrutha P. Thankachan , Gopinathan Anilkumar

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Abstract

This review focuses exclusively on the transition metal-catalyzed hydroamination of strained ring including methylene cyclopropanes, cyclopropenes, cyclobutenes, and norbornenes. Hydroamination comprises the addition of an amine across a carbon-carbon unsaturated bond, resulting in the formation of a new carbon-nitrogen bond. Among the transition metals, Palladium, Copper, and Gold are now being extensively investigated for these reactions. The reactions catalyzed by other transition metals like Co, Ag, Ti, Ir, Rh, etc. are still in the juvenile stage. Intramolecular hydroaminations are generally faster and more versatile than intermolecular processes, with the latter often facing challenges related to regio- and stereoselectivity. This review systematically classifies advancements based on catalytic systems, providing insights into reaction mechanisms, synthetic methodologies, and potential applications. A comprehensive survey of literature from 1988 to 2024 has been conducted to present an in-depth analysis of this field.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.