The effect of amphiregulin on equine endometrial fibroblasts: in vitro responses of fibroblast derived from non-fibrotic and fibrotic endometrium

IF 2.5 3区生物学 Q3 REPRODUCTIVE BIOLOGY

Reproductive biology Pub Date : 2025-04-14 DOI:10.1016/j.repbio.2025.101018

Anna Wójtowicz, Agnieszka Sadowska, Katarzyna Piotrowska-Tomala, Anna Szóstek-Mioduchowska

引用次数: 0

Abstract

The role of AREG in the development of fibrosis in the progression of endometrosis in mare remains unknown. We aimed to determine the effects of AREG on fibroblast functional characteristics as well as the expression of extracellular matrix (ECM)-associated genes in fibroblast derived from non-fibrotic and fibrotic equine endometria. Our findings suggest that the mechanisms associated with ECM remodeling regulated by AREG in non-fibrotic fibroblasts may be dysregulated in the progression of fibrosis in endometrosis.

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安非他酮对马子宫内膜成纤维细胞的影响：非纤维化和纤维化子宫内膜成纤维细胞的体外反应

AREG在子宫内膜异位症进展中纤维化的作用尚不清楚。我们的目的是确定AREG对来自非纤维化和纤维化马子宫内膜的成纤维细胞功能特征以及细胞外基质（ECM）相关基因表达的影响。我们的研究结果表明，非纤维化成纤维细胞中由AREG调节的ECM重塑相关机制可能在子宫内膜异构症纤维化的进展中失调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive biology 生物-生殖生物学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

29 days

期刊介绍： An official journal of the Society for Biology of Reproduction and the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn, Poland. Reproductive Biology is an international, peer-reviewed journal covering all aspects of reproduction in vertebrates. The journal invites original research papers, short communications, review articles and commentaries dealing with reproductive physiology, endocrinology, immunology, molecular and cellular biology, receptor studies, animal breeding as well as andrology, embryology, infertility, assisted reproduction and contraception. Papers from both basic and clinical research will be considered.