Pathways and Molecular Mechanisms Governing LDL Receptor Regulation.

IF 16.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation research Pub Date : 2025-04-10 DOI:10.1161/circresaha.124.323578

Heidi M Schmidt,Kelsey E Jarrett,Thomas Q de Aguiar Vallim,Elizabeth J Tarling

引用次数: 0

Abstract

Clearance of circulating plasma LDL (low-density lipoprotein) cholesterol by the liver requires hepatic LDLR (low-density lipoprotein receptor). Complete absence of functional LDLR manifests in severe hypercholesterolemia and premature atherosclerotic cardiovascular disease. Since the discovery of the LDLR 50 years ago by Brown and Goldstein, all approved lipid-lowering medications have been aimed at increasing the abundance and availability of LDLR on the surface of hepatocytes to promote the removal of LDL particles from the circulation. As such a critical regulator of circulating and cellular cholesterol, it is not surprising that LDLR activity is tightly regulated. Despite over half a century's worth of study, there are still many facets of LDLR biology that remain unexplored. This review will focus on pathways that regulate the LDLR and emerging concepts of LDLR biology.

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调控LDL受体的途径和分子机制。

肝脏清除循环血浆LDL（低密度脂蛋白）胆固醇需要肝脏LDLR（低密度脂蛋白受体）。严重高胆固醇血症和过早动脉粥样硬化性心血管疾病时，LDLR功能完全缺失。自从50年前Brown和Goldstein发现LDLR以来，所有被批准的降脂药物都旨在增加肝细胞表面LDLR的丰度和可用性，以促进LDL颗粒从循环中去除。作为循环和细胞胆固醇的关键调节剂，LDLR活性受到严格调节并不奇怪。尽管经过了半个多世纪的研究，LDLR生物学的许多方面仍未被探索。本文将重点介绍LDLR的调控途径和LDLR生物学的新兴概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation research 医学-外周血管病

CiteScore

29.60

自引率

2.00%

发文量

535

审稿时长

3-6 weeks

期刊介绍： Circulation Research is a peer-reviewed journal that serves as a forum for the highest quality research in basic cardiovascular biology. The journal publishes studies that utilize state-of-the-art approaches to investigate mechanisms of human disease, as well as translational and clinical research that provide fundamental insights into the basis of disease and the mechanism of therapies. Circulation Research has a broad audience that includes clinical and academic cardiologists, basic cardiovascular scientists, physiologists, cellular and molecular biologists, and cardiovascular pharmacologists. The journal aims to advance the understanding of cardiovascular biology and disease by disseminating cutting-edge research to these diverse communities. In terms of indexing, Circulation Research is included in several prominent scientific databases, including BIOSIS, CAB Abstracts, Chemical Abstracts, Current Contents, EMBASE, and MEDLINE. This ensures that the journal's articles are easily discoverable and accessible to researchers in the field. Overall, Circulation Research is a reputable publication that attracts high-quality research and provides a platform for the dissemination of important findings in basic cardiovascular biology and its translational and clinical applications.