Improved Efficacy of Triple-Negative Breast Cancer Immunotherapy via Hydrogel-Based Co-Delivery of CAR-T Cells and Mitophagy Agonist (Adv. Sci. 14/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-04-10 DOI:10.1002/advs.202570094

Guodong Li, Ruoxin Du, Donghui Wang, Xiangmei Zhang, Lizhuo Wang, Shuangpeng Pu, Xiaoju Li, Shuning Wang, Juliang Zhang, Beichen Liu, Yuan Gao, Huadong Zhao

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引用次数: 0

Abstract

CAR-T-Cell Therapy

In article number 2409835 by , Beichen Liu, Yuan Gao, Huadong Zhao, and co-workers, injection hydrogels are engineered for the controlled co-delivery of CAR-T cells and BC1618 that improves the treatment of TNBC. On the cover: The ocean currents represent the delivery medium of CAR-T cells, which is the hydrogel. The schools of small fish swimming around symbolize BC1618, an agonist that can enhance the function of CAR-T cells. The shark represents tumor cells, while the narwhal represents CAR-T cells with enhanced attack power after being delivered by the hydrogel. The dolphins in the background represent regular CAR-T cells, which have relatively weaker attack power.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.