Rational Design of Natural Xanthones Against Gram-negative Bacteria (Adv. Sci. 14/2025)

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-04-10 DOI:10.1002/advs.202570099

Xiaojia Liu, Meirong Song, Ying Liu, Shuyu Yang, Shang Chen, Jijun Kang, Jianzhong Shen, Kui Zhu

引用次数: 0

Abstract

Gram-negative Bacteria

Most antibiotics are ineffective against Gram-negative bacteria due to the presence of the outer membrane (OM). In article number 2411923, Jianzhong Shen, Kui Zhu, and co-workers screened natural xanthone skeletons with the potential to penetrate the OM after amine modification. These optimized compounds cross the OM via a self-promoted pathway, facilitating the discovery of novel antibacterial agents.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.