Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?

IF 4.9 Q1 CHEMISTRY, MEDICINAL

ACS Pharmacology and Translational Science Pub Date : 2025-03-19 DOI:10.1021/acsptsci.5c0012210.1021/acsptsci.5c00122

Saroj Kumar Panda, Shashi Singh and Parth Sarthi Sen Gupta*,

引用次数: 0

Abstract

The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with rationale and supporting evidence that the binding of fibrinogen to its more conserved NTD is an immune evasion strategy adopted by the virus to outsmart the NTD targeted neutralizing antibodies.

查看原文本刊更多论文

刺突蛋白-纤维蛋白原相互作用：一种新的SARS-CoV-2免疫逃避策略？

研究发现，宿主蛋白纤维蛋白原与 SARS-CoV-2 中尖峰蛋白的 N 端结构域（NTD）相互作用。然而，这种结合对病毒进化的益处仍不清楚。在此，我们提出了这样的理由和支持性证据，即纤维蛋白原与其更保守的NTD结合是病毒采取的一种免疫逃避策略，以躲避NTD靶向中和抗体的攻击。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Pharmacology and Translational Science Medicine-Pharmacology (medical)

CiteScore

10.00

自引率

3.30%

发文量

133

期刊介绍： ACS Pharmacology & Translational Science publishes high quality, innovative, and impactful research across the broad spectrum of biological sciences, covering basic and molecular sciences through to translational preclinical studies. Clinical studies that address novel mechanisms of action, and methodological papers that provide innovation, and advance translation, will also be considered. We give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines. Therefore, studies that employ a complementary blend of in vitro and in vivo systems are of particular interest to the journal. Nonetheless, all innovative and impactful research that has an articulated translational relevance will be considered. ACS Pharmacology & Translational Science does not publish research on biological extracts that have unknown concentration or unknown chemical composition. Authors are encouraged to use the pre-submission inquiry mechanism to ensure relevance and appropriateness of research.