Mo-Mediated Reductive Cyclization/Allylation of 2-Alkynyl Nitroarenes with 1,3-Dienes: Synthesis of 3-Allylindoles

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-28 DOI:10.1021/acs.orglett.5c0062410.1021/acs.orglett.5c00624

Jia-Yi Feng, Jian-Bang Hu, Yi Liu, Yong-Yu He, Hongguang Li* and Jin-Bao Peng*,

引用次数: 0

Abstract

3-Allylindoles constitute a key structural feature in many natural products and bioactive compounds. In this work, we developed a Mo-mediated reductive cyclization/allylation of 2-alkynyl nitroarenes with 1,3-dienes. Using Mo(CO)₆ as both the reductant and the catalyst, a broad range of functionalized 3-allylindoles were prepared in good to excellent yields from easily available 2-alkynylnitroarenes and 1,3-dienes as starting materials.

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2-炔基硝基芳烃与1,3-二烯的还原环化/烯丙基化：3-烯丙啉的合成

3-烯丙基吲哚是许多天然产物和生物活性化合物的关键结构特征。在这项工作中，我们开发了一种钼介导的 2-炔基硝基烯烃与 1,3-二烯的还原环化/烯丙基化反应。利用 Mo(CO)6 作为还原剂和催化剂，我们以易于获得的 2-炔基硝基烯烃和 1,3-二烯作为起始原料，制备出了多种官能化的 3-烯丙基吲哚，收率从良好到极佳。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.