Treg cells augment self-tolerance during infection

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-04-10 DOI:10.1038/s41590-025-02141-7

Ryoji Kawakami, Shimon Sakaguchi

引用次数: 0

Abstract

A fine balance is needed for Treg cells to enable immune responses to pathogens without triggering autoimmunity. Data now show that thymus-derived self-peptide-specific Treg cells suppress conventional T cells during infection, but enable immune responses to pathogen-derived peptides, thus promoting self–nonself discrimination.

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Treg细胞在感染过程中增强自身耐受性

Treg细胞需要一个良好的平衡，以使对病原体的免疫反应不触发自身免疫。现在的数据显示，胸腺来源的自身肽特异性Treg细胞在感染期间抑制常规T细胞，但使免疫应答病原体来源的肽，从而促进自我非自我区分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.