Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy

Abstract

Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of 90Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enable a more accurate simulation of the biodistribution of resin and glass microspheres.