Annika M Hansen, Sonia Mehra, Anneli R Bowen, Joseph Sherbotie, Sarah D Cipriano
{"title":"Management of Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Patient With Topical Cidofovir and Oral Leflunomide.","authors":"Annika M Hansen, Sonia Mehra, Anneli R Bowen, Joseph Sherbotie, Sarah D Cipriano","doi":"10.1111/petr.70080","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This case report describes a 10-year-old male with a history of kidney transplantation who developed trichodysplasia spinulosa (TS), a rare skin disorder associated with immunosuppression.</p><p><strong>Methods: </strong>The patient's condition, characterized by follicular papules and keratinous spines primarily on the face, was managed by a multidisciplinary team.</p><p><strong>Results: </strong>Treatment involved reducing immunosuppression and administering topical cidofovir alongside oral leflunomide, leading to significant clinical improvement over several months.</p><p><strong>Conclusions: </strong>This case adds to the literature of TS management and highlights the importance of multidisciplinary care as well as the challenges of treatment accessibility due to insurance limitations.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"29 3","pages":"e70080"},"PeriodicalIF":1.2000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979675/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/petr.70080","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: This case report describes a 10-year-old male with a history of kidney transplantation who developed trichodysplasia spinulosa (TS), a rare skin disorder associated with immunosuppression.
Methods: The patient's condition, characterized by follicular papules and keratinous spines primarily on the face, was managed by a multidisciplinary team.
Results: Treatment involved reducing immunosuppression and administering topical cidofovir alongside oral leflunomide, leading to significant clinical improvement over several months.
Conclusions: This case adds to the literature of TS management and highlights the importance of multidisciplinary care as well as the challenges of treatment accessibility due to insurance limitations.
期刊介绍:
The aim of Pediatric Transplantation is to publish original articles of the highest quality on clinical experience and basic research in transplantation of tissues and solid organs in infants, children and adolescents. The journal seeks to disseminate the latest information widely to all individuals involved in kidney, liver, heart, lung, intestine and stem cell (bone-marrow) transplantation. In addition, the journal publishes focused reviews on topics relevant to pediatric transplantation as well as timely editorial comment on controversial issues.