Unraveling The Impact of Viral Infections on Sperm Genetic Stability: A Scoping Review.

Abstract

Despite the apparent resilience of the male reproductive system, various viruses have been found to impact male fertility by causing testicular inflammation, hormonal imbalances, and sperm abnormalities. The integrity of the genome is vital for cell function, and its instability, influenced by various factors including viral infections, may contribute to age-related conditions such as cancer and neurodegenerative disorders. This scoping review aims to investigate the relationship between viral infections and sperm genetic stability, exploring their interactions and potential impact on male reproductive health and fertility. In order to conduct this scoping review, PubMed, MEDLINE (OVID), ScienceDirect, Google Scholar, and Cochrane databases were explored to find the relevant articles using a search strategy developed in collaboration with a medical librarian. Two independent reviewers screened titles and abstracts of the relevant papers, followed by full-text screening. Studies focusing on infertile males with viral infections, compared to fertile males, examining DNA damage and sperm abnormalities were included. Thirty-four studies were included in the current review. This review will provide valuable information to healthcare professionals in addressing virusinduced sperm genetic instability and its implications for reproductive health. Furthermore, it highlights the socioeconomic and public health aspects of preventing and managing viral infections.