Network analysis and in vivo experiments reveal the therapeutic mechanisms of total ginsenosides in a Drosophila model of ulcerative colitis.

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY

Frontiers in Pharmacology Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI:10.3389/fphar.2025.1556579

Gongchen He, Jian Sun, Yuexin Gu, Yanjie Zheng, Liang Wang, Yanyan Sun

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Abstract

Gut homeostasis is critical for human health, ulcerative colitis (UC) can disrupt gut homeostasis and cause disease. Panax ginseng C.A. Meyer is a widely used traditional herbal medicine known for its anti-inflammatory, antioxidant, and immunomodulatory effects. However, the protective mechanisms of total ginsenosides (TG) in treating UC remain unclear. In this study, we employed Drosophila melanogaster as a model organism to investigate the protective effects of TG on dextran sulfate sodium (DSS)-induced intestinal injury. Our data showed that TG significantly improved survival rates in female flies, restored intestinal length, maintained intestinal barrier integrity, and alleviated oxidative stress. Additionally, TG may protect against intestinal damage by activating the PI3K/Akt signaling pathway and inhibiting the JAK/STAT signaling pathway. These findings suggest that TG alleviates UC symptoms through multi-target regulation, highlighting its potential for developing novel therapeutic strategies for UC.

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网络分析和体内实验揭示了人参总皂苷对溃疡性结肠炎果蝇模型的治疗机制。

肠道内稳态对人体健康至关重要，溃疡性结肠炎（UC）可破坏肠道内稳态并引起疾病。人参是一种广泛使用的传统草药，以其抗炎、抗氧化和免疫调节作用而闻名。然而，总人参皂苷（TG）治疗UC的保护机制尚不清楚。本研究以黑腹果蝇为模型生物，研究TG对葡聚糖硫酸钠（DSS）诱导的肠道损伤的保护作用。我们的数据显示，TG显著提高了雌性果蝇的存活率，恢复了肠道长度，保持了肠道屏障的完整性，并减轻了氧化应激。此外，TG可能通过激活PI3K/Akt信号通路和抑制JAK/STAT信号通路来保护肠道损伤。这些发现表明TG通过多靶点调节减轻UC症状，突出了其开发UC新治疗策略的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

7.80

自引率

8.90%

发文量

5163

审稿时长

14 weeks

期刊介绍： Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.