Neurological sequalae in pediatric patients with CNS tumors after radiation treatment: A comprehensive review

Abstract

Radiation therapy plays a pivotal role in treating pediatric central nervous system (CNS) tumors. However, its potential long-term impact on neurological function poses significant challenges. In this review, we examine the scope of neurological sequelae in survivors of pediatric CNS tumors, with a focus on clinical manifestations, evaluation methods, and management strategies. Key areas discussed include neurocognitive deficits, endocrine dysfunctions, cerebrovascular complications, and secondary malignancies. Emphasis is placed on mitigating radiation-induced toxicity through advanced radiotherapy techniques and integrated survivorship care.